EC Number   |
General Information |
Reference |
|---|
   3.4.24.40 | evolution |
the calcium-regulated alkaline protease is a member of the repeats in toxin, RTX, family of proteins |
717874 |
| 3.4.24.40 | malfunction |
strain K904 with deletion of both prtS and slpB genes is defective in secreted protease activity and cytotoxicity to human cell lines |
-, 733971 |
| 3.4.24.40 | more |
the enzyme is compatible at 60°C with commercial detergents |
717655 |
| 3.4.24.40 | physiological function |
the alkaline protease AprA is associated with bacterial virulence and interferes with complement-mediated lysis of erythrocytes and complement activation. AprA potently blocks phagocytosis and killing of Pseudomonas by human neutrophils. AprA inhibits opsonization of bacteria with C3b and the formation of the chemotactic agent C5a. AprA specifically blocks C3b deposition via the classical and lectin pathways, whereas the alternative pathway is not affected. AprA degrades both human C1s and C2, and the mechanism of action for complement inhibition is cleavage of C2, overview |
717946 |
| 3.4.24.40 | physiological function |
the calcium-regulated alkaline protease is implicated in multiple modes of infection |
717874 |
| 3.4.24.40 | physiological function |
the enzyme exhibits cytotoxicity to airway and ocular cell lines in vitro |
-, 733971 |
