EC Number   |
General Information |
Reference |
|---|
   3.4.24.17 | evolution |
despite their similar substrate specificities, the stromelysins show differential patterns of transcriptional regulation and tissue distribution that hint at distinct physiological functions in processes such as skeletal development, wound healing, and vascular remodeling |
734175 |
| 3.4.24.17 | malfunction |
coexpression of MMP3 with activated KRAS in pancreatic acinar cells stimulates metaplasia and immune cell infiltration, priming the stromal microenvironment for early tumor development in a transgenic mouse model |
734672 |
| 3.4.24.17 | malfunction |
knockout of MMP-3 attenuates vascular smooth muscle cell migration through reduced MMP-9 activation |
717168 |
| 3.4.24.17 | malfunction |
MMP-3 is involved in breast cancer cell invasiveness |
707004 |
| 3.4.24.17 | malfunction |
MMP-3 is involved in glioma cell invasion, overview |
708089 |
| 3.4.24.17 | malfunction |
MMP-3 is strongly expressed in tumor and arthritis specimens |
-, 708420 |
| 3.4.24.17 | malfunction |
psychosine-induced globoid cell formation from microglia is prevented by either genetic ablation or chemical inhibition of enzyme MMP-3. Elevated expression of MMP-3 in globoid cell leukodystrophy or Krabbe disease, a fatal demyelinating disease, may promote microglial responses to psychosine that may represent an important pathophysiological process in this disease and its treatment |
-, 733946 |
| 3.4.24.17 | malfunction |
reduced MMP-3 expression in invasive trophoblasts of patients with severe preeclampsia |
710257 |
| 3.4.24.17 | malfunction |
the intracellular Dengue virus loads are significantly higher in MMP3 silenced cells compared with controls. The expression level of selective anti-viral cytokines are decreased in MMP3 siRNA treated cells, and the transcription factor activity of NFkappaB is significantly impaired upon MMP3 silencing during Dengue virus infection |
735131 |
| 3.4.24.17 | metabolism |
NF-kappaB and AP-1 are important transcription factors for MMP-3 gene expression. Glycitein, a bacterial metabolite of the isoflavone glycitin, inhibits glioma cell invasion through downregulation of MMP-3 and MMP-9 gene expression, overview |
708089 |
