EC Number   |
General Information |
Reference |
|---|
   3.4.23.24 | malfunction |
Sap1 to Sap6 do not play a significant role in Candida albicans virulence in a murine model of hematogenously disseminated candidiasis. In this model, Sap1 to Sap3 are not necessary for successful Candida albicans infection. A deficiency in SAP4 to SAP6 has no noticeable impact on the immune response elicited in the spleens and kidneys of Candida albicans-infected mice |
717659 |
| 3.4.23.24 | malfunction |
the Cgyps1-11 mutant lacking all 11 enzyme genes displays pleiotropic defects, including increased susceptibility to cell wall and osmotic stress, perturbed vacuole and pH homeostasis, and attenuated intracellular survival and pathogenesis |
-, 754172 |
| 3.4.23.24 | physiological function |
isoform Sap2 induces neutrophil migration and production of potent chemoattractive chemokines such as interleukin-8 and macrophage inflammatory protein-2 by vaginal epithelial cells |
755653 |
| 3.4.23.24 | physiological function |
isoform Sap6 induces neutrophil migration and production of potent chemoattractive chemokines such as interleukin-8 and macrophage inflammatory protein-2 by vaginal epithelial cells |
755653 |
| 3.4.23.24 | physiological function |
isoform Sap9 is associated with protein-receptor interactions between fungal cells, and with interkingdom communication in the formation of polymicrobial biofilm communities |
754991 |
| 3.4.23.24 | physiological function |
isoforms Sap1, Sap2, and Sap3 degrade host complement components C3b, C4b and C5 and suppress host complement response. Saps inhibit C3b opsonization of Candida albicans and generation of the anaphylatoxin C5a in human plasma |
709986 |
| 3.4.23.24 | physiological function |
isoforms SAPP1 and SAPP2, but not SAPP3, influence adhesion, host cell damage, phagosome-lysosome maturation, phagocytosis, killing capacity, and cytokine secretion by hu-man peripheral blood-derived macrophages |
754810 |
| 3.4.23.24 | physiological function |
overexpression of Candida albicans secreted aspartyl proteinase 2 or 5 is not sufficient for exacerbation of immunopathology in a mouse model of vaginitis |
753800 |
| 3.4.23.24 | physiological function |
secreted aspartyl proteinase Sap6 mediates virulence in oral candidiasis. Mice infected sublingually with Candida albicans cells overexpressing Sap6 have thicker fungal plaques and more severe oral infection |
-, 753796 |
| 3.4.23.24 | physiological function |
secreted aspartyl proteinases are not involved in invasion and damage of reconstituted human oral epithelium by Candida tropicalis |
717508 |
