EC Number |
General Information |
Reference |
---|
3.4.22.65 | evolution |
enzyme Der p 1 is a cysteine protease from the papain family |
731348 |
3.4.22.65 | evolution |
mannosylation is a unique feature of the allergens within the cysteine protease family of enzymes, e.g. Der 1 p, papain, and bromelain, while non-allergens of the family, e.g. calpain, and cysteine protease B do not show mannosylation in their carbohydrate patterns, staphopain B is also a cysteine protease protein, like Der p 1, but is an amannosylated antigen |
732689 |
3.4.22.65 | more |
activation mechanism analysis of the two other serine proteases, Der p 6 (chymotrypsin-like) and Der p 9 (collagenase)zymogen by mite protease Der p 1, overview |
731348 |
3.4.22.65 | more |
binding properties of in tobacco plant-produced I-rDer p 1 versus the IgE of patients sera are comparable to those obtained on Der p 1 preparation immobilized on a microarray |
732955 |
3.4.22.65 | more |
Dermatophagoides farinae allergen Der f1 is one of the most important indoor allergens associated with allergic diseases in humans |
732926 |
3.4.22.65 | more |
the enzyme is a group 1 mite allergen |
731895 |
3.4.22.65 | more |
the enzyme is bound by the mannose receptor of dendritic cells, the recombinant enzyme binds stronger due to its higher degree of mannans compared to the native enzyme |
732689 |
3.4.22.65 | more |
the Group 7 as well as the Group 2 mite allergens are structurally similar to different proteins in the TLR pathway |
717698 |
3.4.22.65 | physiological function |
Der p 7 elicits strong IgE antibody and T-cell responses in mite allergic patients. Sensitization to house dust mite allergens is strongly correlated with asthma. The allergen function may contribute to allergenicity, e.g. the protease activity of Group 1 mite allergens, and the interaction with the innate immune system by Group 2 mite allergens |
717698 |
3.4.22.65 | physiological function |
Der p1 activates the human receptor mas-related G-protein-coupled receptor X1 and the mouse homolog mas-related G-protein-coupled receptor C11. Der p1 also induces the release of IL-6 from heterologous cells expressing mas-related G-protein-coupled receptor X1 |
754147 |