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Results 1 - 10 of 60 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61evolution caspase-3 is an executioner caspase 717272
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61evolution initiator and executioner caspases, the pro-apoptotic members of the caspase family are subdivided in the initiators of apoptosis and the executioners of apoptosis. Caspase-18 and the ancestor of -8 and -10 called caspase-810 in this schematic are still found in fishes. Later on in evolution, caspase-8 and -10 branched off from caspase-810 717282
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61evolution initiator and executioner caspases, the pro-apoptotic members of the caspase family are subdivided in the initiators of apoptosis, i.e. caspases-8, -9 and -10 in humans, and the executioners of apoptosis, caspase-3, -6 and -7, phylogenetic tree of all the human caspases, overview. The initiators have a relatively large N-terminal dimerization domain, either a death effector domain, caspases-8 and -10, or a structurally related caspase recruitment domain, caspase-9. Caspase-18 and the ancestor of -8 and -10 called caspase-810 in this schematic are still found in fishes. Later on in evolution, caspase-8 and -10 branched off from caspase-810 717282
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction caspase 8 knockdown stabilizes both cellular inhibitor of apoptosis 1, cIAP-1, and X-linked IAP, XIAP 717576
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction caspase-8 inhibition decreases biofilm cell survival -, 709486
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction caspase-8 is coupled with the regulation of various neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease and dentatorubral pallidoluysian atrophy 731391
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction cells lacking in caspase-8 show reduced adhesion to fibronectin with concomitant reduction in adhesion-induced ERK 1/2 activation, these effects can be restored upon reexpression of either the wild-type or catalytically inactive point mutant protein, implying caspase-8 is involved to promote cell adhesion and adhesion-induced ERK 1/2 activation independently of its catalytical activity 717900
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction depletion of caspase-8 decreases endogenous amyloid beta-protein production 709626
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction developmental abnormalities of caspase-8-deficient mice 717217
Display the word mapDisplay the reaction diagram Show all sequences 3.4.22.61malfunction failure to express caspase-8 has no effect on the life-span of dendritic cells but instead leads to an enhanced intrinsic activation and subsequently more mature and autoreactive lymphocytes. Mice with conditional deletion of caspase-8 in DCs develop a chronic systemic autoimmune disease 732273
Results 1 - 10 of 60 > >>