EC Number   |
General Information |
Reference |
|---|
   3.4.22.48 | physiological function |
both staphopains (staphopain A and staphopain B) prolong the partial thromboplastin time of plasma in a dose- and activity-dependent manner, with SspB being 3fold more potent than ScpA. Staphopains also prolong the thrombin time of both plasma and fibrinogen, indicating that these enzymes can cause impaired plasma clotting through fibrinogen degradation |
718091 |
| 3.4.22.48 | physiological function |
SspB is a virulence factor. Its function is dependent on the presence of galectin-3. It inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. The enzyme is an inhibitor of galectin-3-mediated ROS production |
-, 753799 |
| 3.4.22.48 | physiological function |
staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis |
-, 731710 |
| 3.4.22.48 | physiological function |
staphopains SspB and ScpA modulate Staphylococcus aureus biofilm integrity. ScpA enzyme has a conserved ability to inhibit biofilm formation |
-, 731911 |
| 3.4.22.48 | physiological function |
the enzyme cleaves collagen into peptide fragments that can support Staphylococcus aureus growth under nutrient-limited conditions |
754596 |
