EC Number   |
General Information |
Reference |
|---|
   3.4.22.45 | evolution |
amino acids essential for the proteolytic activity of ZYMV HC-Pro are distinct from those of the tobacco etch virus HC-Pro, although the amino acid sequences in the proteolytic active domain are conserved among potyviruses |
717316 |
| 3.4.22.45 | malfunction |
a point mutation in the highly conserved FRNK box produces the HC-ProFINK protein that shows no sRNA binding |
718356 |
| 3.4.22.45 | malfunction |
accumulation of potato virus A is significantly reduced in the HIP2-silenced leaves of Nicotiana benthamiana |
732543 |
| 3.4.22.45 | malfunction |
point mutations introduced to a 4E binding motif identified in the C-terminal region of HCpro debilitate interactions of HCpro with translation initiation factors and are detrimental to the virulence of PVA in plants |
-, 718061 |
| 3.4.22.45 | malfunction |
substitution mutations introduced into the HCpro open reading frame in a tobacco vein banding mosaic virus infectious clone result in changes of Asp189 to Lys or Ile250-Gln251 to Asp-Glu. These amino acid changes eliminate the RNA silencing suppression activity of the mutant HCpro (HCm) and attenuate the disease symptoms caused by the mutant Tobacco vein banding mosaic virus (T-HCm) in Nicotiana benthamiana plants |
754785 |
| 3.4.22.45 | metabolism |
helper component proteinase is a viral suppressor of RNA silencing |
754686 |
| 3.4.22.45 | metabolism |
interaction with HCPro interacting protein 2 (HIP2) and blocking of HIP2 activity. Interaction with translation initiation factor eIF4E/eIF(iso)4E and recruitment of translation initiation factors. Interaction with viral proteins VPg and CI and allocation of the proteins at the tip of virions |
754787 |
| 3.4.22.45 | metabolism |
interaction with HCPro interacting protein 2 (HIP2) and blocking of HIP2 activity. Involved in the formation of cytoplasmic granules and recruitment of both host and viral factors. Interaction with translation initiation factor eIF4E/eIF(iso)4E and recruitment of translation initiation factors. Interaction with viral proteins VPg and CI and allocation of the proteins at the tip of virions |
754787 |
| 3.4.22.45 | metabolism |
interaction with NtMinD, NtDXS, CF1beta-subunit of chloroplast ATP synthase and ferrodoxin-5. Reduction of the photosynthesis rate of the host |
754787 |
| 3.4.22.45 | metabolism |
interaction with PAA, PBB, PBE or PAE proteasome subunits. Inhibition of the 20S proteasome. Interaction with NtMinD, NtDXS, CF1beta-subunit of chloroplast ATP synthase and ferrodoxin-5. Reduction of the photosynthesis rate of the host. Interaction with HCPro interacting protein 2 (HIP2) and blocking of HIP2 activity |
754787 |
