EC Number |
General Information |
Reference |
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3.4.22.43 | malfunction |
increased cathepsin V promoted the degradation of DUSP6 and DUSP7, phosphorylation and subsequent nuclear translocation of ERK1/2, phosphorylation of STAT1 and expression of interleukin (IL)-6, IL-8 and TNF-alpha |
753117 |
3.4.22.43 | malfunction |
lack of cathepsins prevent the development of lung granulomas in a mouse model of Besnier-Boeck-Schaumann (BBS) disease, sarcoidosis. Cathepsin V (Cath V) in bronchoalveolar lavage fluid (BALF) in humans |
752418 |
3.4.22.43 | malfunction |
melanosome degradation is suppressed in CTSV knockdown cells. Inhibition of CTSV expression increases melanosome accumulation in HaCaT keratinocytes. The rate of melanosome degradation is reduced in CTSV knockdown keratinocytes |
752678 |
3.4.22.43 | malfunction |
RNAi-mediated depletion of the enzyme effectively abrogates ectopic E2F1-induced apoptosis, coupled with reduced lysosomal membrane permeabilization and mitochondrial membrane depolarization. Enzyme knockdown also inhibits apoptosis mediated by the endogenous E2F1 activated by DNA damage. Enzyme depletion in cancer cells results in inhibition of histone deacetylase inhibitor-induced apoptosis |
732591 |
3.4.22.43 | metabolism |
cathepsin V and endostatin may represent an index of pulmonary sarcoidosis activity |
752418 |
3.4.22.43 | metabolism |
cathepsin V participates in the production of enkephalin and neuropeptide Y neurotransmitters in secretory vesicles |
732049 |
3.4.22.43 | metabolism |
effects of cathepsin V on the dual-specificity protein phosphatases (DUSPs) and MAPK pathways |
753117 |
3.4.22.43 | physiological function |
cathepsin like 2 is required for E2F1-induced apoptosis by engaging lysosomal membrane permeabilization. Its level also modulates the cellular sensitivity to histone deacetylase inhibitor |
732591 |
3.4.22.43 | physiological function |
CTSV is involved in the breakdown of corneodesmosomal proteins |
709405 |
3.4.22.43 | physiological function |
enzyme cathepsin V (CTSV) is involved in melanosome degradation in the keratinocytes derived from lightcolored skin. It is one of the factors regulating pigmentation |
752678 |