EC Number   |
General Information |
Reference |
|---|
   3.4.21.B45 | malfunction |
aberrant enzyme activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer |
752891 |
| 3.4.21.B45 | metabolism |
both KLK14 and trypsin are able to activate MAP kinase signalling in the human HEK cells as does the PAR-activating peptide, while KLK8 does not |
731398 |
| 3.4.21.B45 | more |
enzyme structure homology modelling using crystal structure, PDB 2BDG, overview |
731395 |
| 3.4.21.B45 | physiological function |
human enzyme can activate rat and human proteinase-activated receptor 2, PAR2, calcium signalling, and the enzyme stimulates human PAR2 clustering and internalization |
731398 |
| 3.4.21.B45 | physiological function |
important protease in skin desquamation |
752891 |
| 3.4.21.B45 | physiological function |
KLK14 (0.0001 mM) induces increases in intracellular Ca2+ in HT-29 cells. KLK14 induces significant extracellular signal-regulated kinases 1 and 2 phosphorylation and HT-29 cell proliferation, presumably by activating proteinase-activated receptor-2 |
717068 |
| 3.4.21.B45 | physiological function |
the enzyme regulates the components of the hepatocyte growth factor/Met axis, pro-hepatocyte growth factor and hepatocyte growth factorF-activator inhibitor 1A and 1B |
752884 |
