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Results 1 - 10 of 27 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77malfunction diminished PSA during acute myocardial infarction and correlation of variation of PSA with coronary lesions and occurrence of major adverse cardiac events. Formation of irreversible PSA complexes (reflected by increased bound PSA) has significant correlation with high-sensitivity C-reactive protein 708774
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77malfunction ligation of prostate cancer cell surface protein GRP78 by its natural ligand, activated alpha2-macroglobulin, results in a 2-3-fold upregulation in the synthesis of PSA. The PSA is secreted into the medium as an active proteinase, where it binds to native alpha2-macroglobulin. The resultant alpha2-macroglobulin-PSA complexes bind to GRP78, causing a 1.5-2fold increase in the activation of MEK1/2, ERK1/2, S6K, and Akt, which is coupled with a 2-3-fold increase in DNA and protein synthesis 717820
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77malfunction recombinant mutant PSA, that lacks enzymatic activity towards a small chromogenic PSA substrate, also exerts antiangiogenic activity. HUVEC tube formation model shows that inactive PSA isoforms do not have antiangiogenic activity. Inhibition of PSA, either by a monoclonal antibody or small molecule inhibitors abolishes the effect of PSA 710554
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77metabolism the HSP protein family and the gama-SM protein are related in two critical ways: the fact that silencing HSPs may be directly correlated with reduced gama-SM protein expression and their high potential as biomarkers for PCa. A direct proportional relationship between Hsp70 and the gama-SM protein 753651
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77more in circulation, the majority of the enzyme is complexed with protease inhibitors, including alpha1-antichymotrypsin. The proportion of the enzyme-alpha1-antichymotrypsin complex is higher in patients with prostate cancer than in controls without cancer 732851
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77more the enzyme is a chymotrypsin-like serine protease 731135
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77physiological function 125I-labeled specific monoclonal antibodies demonstrate strong binding to PSA on the surface of LNCaP cells 708676
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77physiological function a faster time to reach a PSA nadir after the initiation of androgen-deprivation therapy is associated with shorter survival duration in men with metastatic hormone-sensitive prostate cancer. Association between time to PSA nadir and survival is limited only to patients who have a PSA nadir more than 0.2 ng/ml 708000
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77physiological function active PSA exerts chymotrypsin-like enzymatic activity and efficiently digests semenogelins, which leads to liquefaction of the seminal clot. PSA inhibits angiogenesis both in in vitro and in vivo models. The antiangiogenic activity of PSA is related to its enzymatic activity and may be associated with the slow growth of prostate cancer. Purified PSA reduces the fibroblast growth factor 2-stimulated proliferation of HUVECs, bovine adrenal capillary endothelial cells and human microvascular dermal cells, while B16BL6 and human prostate cancer (PC3) cells are unaffected. Angiogenesis inducing cysteine-rich 61 is dramatically down-regulated by PSA in PC-3M and LNCaP prostate cancer cell lines. Inhibitory effect of enzymatically active PSA in seminal fluid is dose-dependent and significant inhibition is observed at a concentration of 0.0001 mM, which is over 10fold lower that found in the extracellular fluid in the prostate. Subcutaneously injected PSA reduces angiogenesis and xenograft tumor growth in mice and subcutaneously administered PSA reduces the metastatic propensity of intravenously injected melanoma cells 710554
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.77physiological function after treatment with recombinant semenogelin, spermatozoa can be washed and treated with PSA, partially reversing the inhibition of progressive motility 707639
Results 1 - 10 of 27 > >>