EC Number   |
General Information |
Reference |
|---|
   3.4.21.72 | evolution |
expression of IgA proteases is variable from strain to strain among NTHi. Analysis of IgA protease expression by 101 persistent strains (median duration of persistence) collected longitudinally from patients enrolled in a 20-year study of COPD upon initial acquisition and immediately before clearance from the host. Upon acquisition, 89 (88%) express IgA protease. A total of 16 of 101 (16%) strains of NTHi alter expression of IgA protease during persistence. Indels and slipped-strand mispairing of mononucleotide repeats confer changes in expression of igaA2. Mechanism of changes in expression, overview |
753802 |
| 3.4.21.72 | evolution |
Haemophilus influenzae 49247 IgA protease shows unique DNA and amino acid sequence but with typical endopeptidase domain and beta transporter domain compared to known IgA proteases from the same species |
-, 754698 |
| 3.4.21.72 | evolution |
Haemophilus influenzae has likely acquired igaB from Neisseria meningitidis, the acquisition is accompanied by a about 20 kb genomic inversion that is present only in strains that have igaB, overview |
718295 |
| 3.4.21.72 | malfunction |
the IgA1/IgA2 ratio is 6.3 for the healthy volunteers and 12.8 for patients with meningitis. IgA2 for the patients with meningitis and the healthy volunteers are almost unchanged, 1:86 and 1:121, respectively |
-, 753051 |
| 3.4.21.72 | more |
IgA1 protease isolated from serogroup A meningococcus is capable of protecting experimental mice infected with meningococcus of serogroup B |
718393 |
| 3.4.21.72 | more |
immunization of mice with recombinant IgA1 protease of Neisseria meningitidis or several structural derivatives thereof protects the animals infected with a variety of deadly pathogens, including Neisseria meningitidis serogroups A, B, and C and 3 serotypes of Streptococcus pneumonia. In sera of rabbits immunized with inactivated pneumococcal cultures, antibodies binding IgA1-protease from Neisseria meningitidis serogroup B are detected. Cross-reactive protection against meningococcal and pneumococcal infections in vivo |
-, 754644 |
| 3.4.21.72 | more |
the enzyme, isolated from meningococcus serogroup A, is capable of protecting mice infected with meningococcus of serogroup B |
717322 |
| 3.4.21.72 | more |
the secreted 150 kDa meningococcal ST-11 IgA protease is carrying nuclear localisation signals (NLS) in its alpha-peptide moiety that allow efficient intranuclear transport in the host Hec-1-B cells |
755202 |
| 3.4.21.72 | physiological function |
ability of IgA1 protease to cleave exclusively IgA1 without affecting IgA2 molecules |
-, 753051 |
| 3.4.21.72 | physiological function |
enzyme IgA1P cleaves human immunoglobulin A1 (IgA1), the predominant antibody on human mucosal surfaces. The actions of IgA1Ps impede IgA1 from neutralizing the bacteria. Specifically, IgA1P cleaves IgA1 at a unique hinge region, separating the Fc and Fab fragments of the immunoglobulin. This impairs its Fc-mediated effector response and can even allow bacteria to retain the Fab fragment on their surface in order to mask their polysaccharide capsule and other surface antigens |
752366 |
