EC Number   |
General Information |
Reference |
|---|
   3.4.21.71 | physiological function |
elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome |
717908 |
| 3.4.21.71 | physiological function |
elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome. Transgenic elastase 2 mice display an ichthyotic phenotype |
717908 |
| 3.4.21.71 | physiological function |
expression of ELA2 is associated with histone acetylation in leukemic cell lines. DNA methylation and transcript levels of ELA2 in chronic myeloid leukemia are not correlated |
718106 |
| 3.4.21.71 | physiological function |
the enzyme plays a role in the maintenance of basal hemodynamics, contributing to cardiovascular homeostasis. The enzyme acts on the sympathovagal balance of the heart |
753704 |
| 3.4.21.71 | physiological function |
the enzyme's biological functions include involvement in migration of neutrophils by means of focal proteolysis, killing of microorganisms, and degradation/activation of various proteins including cytokines, chemokines and ECM proteins |
732380 |
