EC Number |
General Information |
Reference |
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3.4.21.38 | malfunction |
congenital blood coagulation factor XII deficiency is a rare coagulation disease and an autosomal recessive trait. The mutation K346N is found in the FXII gene of a patient with FXII deficiency, designated as factor XII Ofunato |
710605 |
3.4.21.38 | malfunction |
enzyme deficiency improves survival and reduces bacterial outgrowth following infection with Klebsiella pneumoniae but has no effect on phagocytosis of bacteria |
755577 |
3.4.21.38 | malfunction |
factor XII inhibition decreases the fibrin formation (5fold) and fibrin density, and increases the fibrinolysis rate when fibrin formation is initiated via the contact activation pathway with long-chain polyphosphate polyP |
752492 |
3.4.21.38 | malfunction |
FXII deficiency in Korean patients leads to prolonged activated partial thromboplastin time |
707841 |
3.4.21.38 | malfunction |
FXIIa is involved in enhanced ischemic stroke risk after induction of cerebral ischemia by either transient or permanent occlusion of the middle cerebral artery, MCAO, overview |
710089 |
3.4.21.38 | malfunction |
genetic ablation of the enzyme protects against neuroinflammation, reduces the formation of atherosclerotic lesions in Apoe-deficient mice, improves wound healing, and inhibits postnatal angiogenesis |
753224 |
3.4.21.38 | malfunction |
genetic deficiency in FXII reduces ex vivo whole-blood thrombus and fibrin formation on immobilized plaque homogenates |
731232 |
3.4.21.38 | malfunction |
hereditary factor XII deficiency does not induce any bleeding phenotype. FXII deficiency prevents pathological thrombus formation, but does not affect regular hemostasis |
718010 |
3.4.21.38 | malfunction |
interaction between FXII and monocyte/macrophages contributes to epithelial ovarian cancer cell invasion and metastasis of the peritoneum. After FXII treatment the cells exhibited M2-polarized phenotypes and show upregulated phagocytic potential. Transcription factors including Fra-1, Fra-2, Fos-B in the AP-1 family, oncogenes HIF-1 and Oct, and STAT-5A in the STAT family are upregulated in FXII-stimulated monocyte/macrophages |
708630 |
3.4.21.38 | malfunction |
the JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts implicating its possible involvement in pathological conditions characterized by elevated TGF-beta1 levels |
709089 |