EC Number   |
General Information |
Reference |
|---|
   3.4.21.114 | malfunction |
the ability of nsp4 to induce apoptosis is significantly impaired by His39, Asp64, and Ser118 mutations |
732736 |
| 3.4.21.114 | more |
residues His39, Asp64, and Ser118 are essential for the enzyme to trigger apoptosis |
732736 |
| 3.4.21.114 | physiological function |
nsp4 inhibits virus-induced IFN-beta production by targeting NF-kappaB essential modulator NEMO for proteolytic cleavage. The scission occurs at sites E166, E171, Q205, and E349 |
754558 |
| 3.4.21.114 | physiological function |
nsp4 inhibits virus-induced IFN-beta production by targeting NF-kappaB essential modulator NEMO for proteolytic cleavage. The scission occurs at sites E166, E171, Q205, and E349. NEMO cleavage at E349 alone may not be sufficient to completely inactivate the interferon response via this signaling adaptor |
754558 |
| 3.4.21.114 | physiological function |
porcine reproductive and respiratory syndrome virus nonstructural protein 4 is a critical apoptosis inducer dependent on its serine protease activity, the full-length of nsp4 structure is required for its apoptosis-inducing activity, the enzyme can induce apoptosis in diverse cell lines, e.g. in HeLa cells, overview |
732736 |
