EC Number   |
General Information |
Reference |
|---|
   3.4.21.107 | evolution |
the enzyme belongs to the HtrA protein family combines chaperone and protease activities and is essential for protein quality control in many organisms. HtrA proteins are composed of a chymotrypsin-like protease domain and one (DegS, HTRA1, HTRA2) or two PDZ domains (DegP, DegQ) |
732565 |
| 3.4.21.107 | malfunction |
Bordetella pertussis lacking the periplasmic chaperone/protease DegP has a strong growth defect at 37°C, and the integrity of its outer membrane is compromised |
713051 |
| 3.4.21.107 | malfunction |
cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy-associated mutant HTRA1 decreases protease activity and fails to decrease transforming growth factor-beta family signaling |
717650 |
| 3.4.21.107 | malfunction |
disruption of the high temperature requirement A gene affects significantly the ability of the resulting mutants to withstand heat, oxidative, ethanol and osmotic stress, exhibit delayed proliferation, and show a decrease of over six orders of magnitude in virulence as compared with the parental wild type strain |
-, 718135 |
| 3.4.21.107 | malfunction |
HTRA1 is involved in complement regulation and amyloid deposition in age-related macular degeneration pathogenesis |
712207 |
| 3.4.21.107 | malfunction |
HTRA1 knockout mice display reduced blood vessel in retina and upregulation of growth differentiation factor 6 |
717871 |
| 3.4.21.107 | malfunction |
lack of nuclear localisation of Nma111p causes late onset of cell death during chronological ageing |
712542 |
| 3.4.21.107 | malfunction |
stable knockdown of HtrA1 in SKOV-3 and TOV-21G cells results in resistance to anoikis due to enhanced activation of epidermal growth factor receptor/AKT pathway. Downregulation of HtrA1 significantly enhances the peritoneal dissemination of SKOV-3ip1 cells in nonobese diabetic/severe combined immunodeficient mice |
711674 |
| 3.4.21.107 | malfunction |
the loss of HTRA activity is correlated with severe diseases, including arthritis, cancer, familial ischemic cerebral smallvessel disease and age-related macular degeneration, as well as Parkinsons disease and Alzheimers disease |
718153 |
| 3.4.21.107 | metabolism |
one of the targets of HtrA1 activity during fetal development is the tuberous sclerosis complex 2-tuberous sclerosis complex 1 pathway |
718104 |
