EC Number   |
General Information |
Reference |
|---|
   3.4.19.6 | metabolism |
fasting enhances pyroglutamyl peptidase II activity in tanycytes of the mediobasal hypothalamus of male adult rats |
753437 |
| 3.4.19.6 | metabolism |
high cholesterol intake modifies pyroglutamyl aminopeptidase activity in serum and different tissues of male and female mice. High cholesterol alters the regulation of this activity on their specific biologically active peptide substrates, mainly TRH and TRH-like peptides, and modifies their specific functions on target organs. Cholesterol administration in females significantly increases membrane-bound pyroglutamyl aminopeptidase-specific activity in liver by 62.03%, but significantly decreases activity in atrium by 56.56% |
753360 |
| 3.4.19.6 | metabolism |
long-term changes in dietary Zn down-regulate pyroglutamyl aminopeptidase II activity independently of triiodothyronine, increasing thyrotropin serum concentration, overall resembling sub-clinical hypothyroidism |
753886 |
| 3.4.19.6 | physiological function |
in the medial septum pyroglutamyl peptidase II activity may limit thyrotropin-releasing hormone action, presumably by reducing the concentration of thyrotropin-releasing hormone in the extracellular fluid around cells coexpressing pyroglutamyl peptidase II and thyrotropin-releasing hormone-receptor 1 |
732377 |
| 3.4.19.6 | physiological function |
pyroglutamyl peptidase II is a thyrotropin releasing hormone (TRH)-degrading ectoenzyme that controls the amount of TRH that reaches the anterior pituitary |
753437 |
| 3.4.19.6 | physiological function |
the enzyme degrades thyrotropin-releasing hormone (TRH) released from the median eminence and participates in hypothalamus-pituitary-thyroid (HPT) axis function by regulating TRH-induced thyrotropin release from adenohypophysis |
753886 |
| 3.4.19.6 | physiological function |
thyrotropin releasing hormone regulates action potential shape in pyramidal cortical neurons, and degrading enzyme pyroglutamyl peptidase II controls its action in this region |
731566 |
