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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.12physiological function both microRNA-146a-5p and carboxypeptidase M regulate Src and FAK expression, while the Src-FAK signaling pathway is associated with the migration and invasion of multiple tumor cells. The functional and mechanistic relationship of the miR-146a-5p/CPM/Src-FAK axis is demonstrated and its effect on the migration and invasion of colorectal cancer cells 754960
Display the word mapDisplay the reaction diagram Show all sequences 3.4.17.12physiological function in HEK-293 cells stably transfected with kinin B1 receptor, co-expression of carboxypeptidase M enhances des-Arg10-kallidin-stimulated increases in intracellular Ca2+ or phosphoinositide turnover. Carboxypeptidase M increases kinin B1 receptor affinity for des-Arg10-kallidin by 5-fold but has no effect on basal kinin B1 receptor-dependent phosphoinositide turnover. Soluble, recombinant carboxypeptidase M binds to HEK cells expressing kinin B1 receptor without stimulating receptor signaling. Carboxypeptidase M positive allosteric action is independent of enzyme activity but depended on interaction of its C-terminal domain with the kinin B1 receptor extracellular loop 2. Disruption of the carboxypeptidase M/kinin B1 receptor interaction or knockdown of carboxypeptidase M in cytokine-treated primary human endothelial cells inhibits the allosteric enhancement of carboxypeptidase M on kinin B1 receptor des-Arg10-kallidin binding or ERK1/2 activation. Carboxypeptidase M also enhances the des-Arg10-kallidin-induced kinin B1 receptor conformational changes 732121
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