EC Number   |
General Information |
Reference |
|---|
   3.4.16.2 | malfunction |
Prcp-null (Prcp-/-) mice eat less and have even less fat than the mice with partial loss of the enzyme. Knockout mice are resistant to diet-induced obesity |
709270 |
| 3.4.16.2 | malfunction |
Prcp-null mice have elevated levels of alpha-melanocyte-stimulating hormone 1-13 in the hypothalamus and aree leaner and shorter than the wild-type controls on a regular chow diet. They are also resistant to high-fat diet-induced obesity |
709271 |
| 3.4.16.2 | physiological function |
at pH values below 6, formation of angiotensin (1-7) in ACE2 knockout mice is similar to that in wild-type mice. The prolyl carboxypeptidase-prolyl endopeptidase inhibitor Z-prolyl-prolinal reduces angiotensin (1-7) formation in ACE2 knockout mice. ACE2 metabolizes angiotensin II in the kidney at neutral and basic pH, while prolyl carboxypeptidase catalyzes the same reaction at acidic pH |
752436 |
| 3.4.16.2 | physiological function |
enzyme participates in the hydrolysis of the insects major dietary proteins, gliadins |
731918 |
| 3.4.16.2 | physiological function |
PRCP expression promotes obesity, while inhibitors of the enzyme counteract obesity |
709270 |
| 3.4.16.2 | physiological function |
PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-melanocyte-stimulating hormone1-13 levels |
709271 |
| 3.4.16.2 | physiological function |
prolyl carboxypeptidase and the related family member prolyl endopeptidase are essential for proliferation and survival of pancreatic cancer cells. Depletion/inhibition of prolyl carboxypeptidase and prolyl endopeptidase induces serine phosphorylation and degradation of insulin receptor substrate IRS-1, leading to inactivation of the cellular PI3K and AKT. Depletion/inhibition of prolyl carboxypeptidase /prolyl endopeptidase destabilized IRS-1 in the cells treated with rapamycin, blocking the feedback activation PI3K/AKT. Inhibition of prolyl carboxypeptidase /prolyl endopeptidase enhances rapamycin-induced cytotoxicity |
732142 |
| 3.4.16.2 | physiological function |
upregulation of PRCP in lipopolysaccharide treated endothelium promotes inflammation |
709380 |
