EC Number   |
General Information |
Reference |
|---|
   3.4.13.20 | malfunction |
HeLa-CN1 cells have a lower cell survival than do non-transfected cells or HeLa cells transfected with an empty or a mock vector. Viability in HeLa cells measured after H2O2 treatment is significantly higher than the viability of HeLa-CN1 cells after the same oxidant insult, indicating an increased susceptibility to oxidative stress of cells overexpressing carnosinase |
707175 |
| 3.4.13.20 | metabolism |
carnosine and anserine are mainly hydrolyzed by carnosinase, a low but significant amount is excreted in the urine. Carnosine reaches a steady state of very low concentration in serum, while anserine sustains higher concentrations than that of carnosine due to its greater stability vis-a-vis carnosinase after ingesting histidine-dipeptide rich diet |
707089 |
| 3.4.13.20 | physiological function |
CN1 activity is lower in children and increases with age with no differences in protein concentration. CN1 activity is considerably higher in serum than in cerebrospinal fluid |
707087 |
| 3.4.13.20 | physiological function |
reduced glutathione, N-acetylcysteine and cysteine lower dose-dependently recombinant CN1 efficiency and normalize increased CN1 activity in renal tissue samples of diabetic mice. Inhibition is allosteric. Only cysteine-102 is influenced by cysteinylation |
754284 |
