EC Number   |
General Information |
Reference |
|---|
   3.4.11.6 | malfunction |
LTB4 levels are persistently elevated in bronchoalveolar lavage fluid (BALF) of lipopolysaccharide (LPS)-induced ALI, and the leukotriene levels in pulmonary edema fluid are significantly higher in ALI patients compared to control patients with hydrostatic pulmonary edema. In addition, LTB4 level is increased in lung homogenates, and BALF of patients with IPF and the level of LTB4 correlate with the extent of fibrosis in histological sections |
754386 |
| 3.4.11.6 | more |
LTA4H folds into three domains and creates a deep cleft harboring the catalytic Zn2+ site, forming the active site with an L-shaped hydrophobic pocket deep into the protein |
754386 |
| 3.4.11.6 | physiological function |
leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme that exhibits LTA4H and aminopeptidase activities |
753286 |
| 3.4.11.6 | physiological function |
leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme that exhibits LTA4H and aminopeptidase activities, it is a key enzyme in the biosynthesis of leukotriene B4 (LTB4). LTA4H is well-known to regulate chemotactic activity of human neutrophils. LTB4 is secreted by neutrophils at inflammation sites in response to formyl peptides, playing an important role in neutrophil activation and migration to formyl peptides |
754386 |
| 3.4.11.6 | physiological function |
when murine ACE2 is given to mice for 4 weeks, a marked increase in serum ACE2 activity is detected. ACE2 leads to the dissipation of Ang II with formation of Ang (1-7) |
731901 |
