EC Number |
General Information |
Reference |
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3.4.11.14 | malfunction |
decrease in activity increases the aggregation and toxicity of expanded huntingtin exon 1, overexpression reduces aggregates and toxicity of mutant huntingtin exon 1 |
717649 |
3.4.11.14 | malfunction |
downregulation of enzyme expression suppresses the proliferation, migration and invasion of PC-3 cells and decreases the secretion and expression of matrix metalloproteinase-9 |
709501 |
3.4.11.14 | physiological function |
catalyses tau protein |
710523 |
3.4.11.14 | physiological function |
cyclin-dependent kinase 5, puromycin-sensitive aminopeptidase A, and calmodulin are all present in isolated nuclei and cyclin-dependent kinase 5 and puromycin-sensitive aminopeptidase co-immunoprecipitate with nuclear calmodulin |
731338 |
3.4.11.14 | physiological function |
elevation of activity in vivo effectively blocks accumulation of soluble hyperphosphorylated TAU protein and slows down the progression of neurodegeneration in the mammalian system |
717651 |
3.4.11.14 | physiological function |
enzyme binds to calmodulin-binding protein nucleomorphin. Bindung does not require calcium |
731572 |
3.4.11.14 | physiological function |
regulates directly Cu,Zn-superoxide dismutase 1 (SOD1) protein abundance and clearance via proteolysis |
718137 |
3.4.11.14 | physiological function |
suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo, decreases aggregate number in cellular models of neurodegenerative diseases, enhances macroautophagy |
717649 |