EC Number   |
General Information |
Reference |
|---|
   3.2.1.207 | evolution |
the enzyme contains a glycoside hydrolase family 31 motif containing the conserved WXDMNE sequence, which is essential for enzymatic activity |
731917 |
| 3.2.1.207 | malfunction |
loss-of-function in the Arabidopsis thaliana glucosidaseII beta-subunit gene confers an polypeptide elf18-insensitive phenotype |
716287 |
| 3.2.1.207 | metabolism |
glucosidase-II has a promiscuous activity as a broad specificity hexosidase |
714044 |
| 3.2.1.207 | more |
high concentration of alpha-glucosidase inhibitors from mulberry leaves accumulate in Bombyx mori by feeding, silkworm does not show any toxic symptom against these inhibitors and N-glycosylation of recombinant proteins is not affected |
731917 |
| 3.2.1.207 | more |
the inability of beta-subunit MRH domain to efficiently recognize glucose eliminates the potential for the beta-subunit to compete with the catalytic alpha-subunit of GII for glucose present in arm A of the N-glycan, ligand binding structures, overview. Possible models for the influence of Trp409 in enzyme activity |
732103 |
| 3.2.1.207 | physiological function |
alpha- and beta-subunits of endoplasmic reticulum resident glucosidase II are essential for stable accumulation and quality control of the elf18 receptor EFR but not the flg22 receptor FLS2, overview. Subunit GIIalpha mediates the catalytic activity of the enzyme whereas subunit GIIbeta directly interacts with and holds GIIalpha in the ER through its ER retention signal. Subunit GIIbeta is required for EFR-mediated anthocyanin repression |
710419 |
| 3.2.1.207 | physiological function |
compared to wild-type, a Gas2 RNAi cell line is much more sensitive to dithiothreitol treatment and has higher levels of autophagy. Both caspase-3 and heat-stressed cell suspension lysate can cleave Gas2, producing a 14 kDa N-terminal fragment. Conditional expression of this C-terminal fragment results in enhanced caspase-3-like activity in the protoplasts under heat stress |
752203 |
| 3.2.1.207 | physiological function |
enzyme null mutants tend to aggregate, display reduced growth rates, have a lower content of cell wall phosphomannan and other changes in cell wall composition, underglycosylated beta-N-acetylhexosaminidase, and have a constitutively activated PKC-Mkc1 cell wall integrity pathway. Cells are also attenuated in virulence in a murine model of systemic infection and stimulated an altered pro- and anti-inflammatory cytokine profile from human monocytes |
-, 744821 |
| 3.2.1.207 | physiological function |
gene Rot2 complements a Saccharomyces cerevisiae Rot2 mutant. When expressed in a Candida albicans rot2 mutant, Sporothrix schenckii Rot2 partially increases the levels of alpha-glucosidase activity, but fails to restore the N-linked glycosylation defect associated to the mutation |
745014 |
| 3.2.1.207 | physiological function |
glucosidase II is a glycan-processing enzyme that trims two alpha1,3-linked glucose residues from N-glycan on newly synthesized glycoproteins. Trimming of the first alpha1,3-linked glucose from Glc2Man9GlcNAc2 is important for a glycoprotein to interact with calnexin/calreticulin, and cleavage of the innermost glucose from GlcMan9GlcNAc2 sets glycoproteins free from the CNX/CRT cycle and allows them to proceed to the Golgi apparatus |
708609 |
