EC Number   |
General Information |
Reference |
|---|
   3.2.1.114 | malfunction |
alpha-mannosidase II deficiency has a minimal effect on N-glycan maturation in most cell types due to the compensation by alpha-mannosidase IIx, ablation of alpha-MII impairs the maturation of N-glycans in intestinal epithelial cells. alpha-mannosidase II (DELTA intestinal epithelial cell) mice are less susceptible to dextran sulfate sodium-induced colitis compared with control littermates. Neutrophil infiltration in the colonic mucosa is attenuated in alpha-mannosidase II (DELTA intestinal epithelial cell) mice. Gene expression levels of neutrophil-attracting chemokines are downregulated in the colonic tissue |
750270 |
| 3.2.1.114 | physiological function |
key enzyme in removal of mannose residues from the maturing oligosaccharide by hydrolyzing the mannosyl glycosidic bond as part of the machinery of complex carbohydrate formation |
707745 |
| 3.2.1.114 | physiological function |
key glycosyl hydrolase in the N-linked glycosylation pathway |
749611 |
| 3.2.1.114 | physiological function |
the Afams1 gene, in contrast to its homologues in Saccharomyces cerevisiae or Aspergillus nidulans, is required for morphogenesis and cellular function in Aspergillus fumigatus |
-, 708612 |
| 3.2.1.114 | physiological function |
the enzyme is important for N-glycosylation of protein in the Golgi apparatus |
709035 |
| 3.2.1.114 | physiological function |
the enzyme is perhaps functioning in the subsequent degradation of extracellular host glycans following their initial digestion by secreted glycosidases |
710392 |
| 3.2.1.114 | physiological function |
the enzyme plays a crucial, but not exclusive, role in the maturation of N-glycans. Intestinal epithelial cell alpha-mannosidase II promotes intestinal inflammation by facilitating chemokine expression |
750270 |
