EC Number   |
General Information |
Reference |
|---|
   3.1.4.50 | malfunction |
GPI-PLD is elevated in patients with insulin resistance or high triglycerides, and in patients with nonalcoholic fatty liver disease, overview |
693991 |
| 3.1.4.50 | malfunction |
plasma enzyme levels are significantly lower in patients with ruptured compared nonruptured abdominal aortic aneurysm which is a result of hemodilution due to hemorrhage in patients with ruptured abdominal aortic aneurysm. The plasma enzyme levels are similar in patients with nonruptured abdominal aortic aneurysm compared to the controls without aneurysm |
729848 |
| 3.1.4.50 | metabolism |
GPI-PLD is involved in the glucose metabolism |
-, 709821 |
| 3.1.4.50 | physiological function |
GPI-PLD directly regulates intracellular diacylglycerol content in primary hepatocytes. Serum GPI-PLD levels are strongly and independently associated with serum alanine transaminase and triglyceride levels in male subjects with metabolic syndrome |
749536 |
| 3.1.4.50 | physiological function |
mice lacking GPI-PLD exhibit glucose intolerance and hepatic steatosis under high-fat and high-sucrose diet. Diacylglycerol content is significantly decreased, and protein kinase PKCepsilon activity is suppressed in the livers of knockout mice |
749536 |
| 3.1.4.50 | physiological function |
serum GPI-PLD level is strongly and independently associated with serum alanine transaminase and triglyceride levels in human male subjects |
749536 |
| 3.1.4.50 | physiological function |
the enzyme may participate in regulating inflammation in atherosclerosis |
729848 |
