EC Number   |
General Information |
Reference |
|---|
   3.1.30.1 | evolution |
the enzyme belongs to the plant S1-like nucleases class of enzymes. Different members of this family are characterized by a surprisingly large variety of catalytic properties, nucleolytic activities of all Arabidopsis thaliana S1-like paralogues, overview. In addition to Zn2+-dependent enzymes, this family also comprises nucleases activated by Ca2+ and Mn2+, which implies that the apparently well-known S1 nuclease active site in plant nucleases is able to cooperate with different activatory ions. Particular members of this class differ in their optimum pH value and substrate specificity. Plant representatives of this family evolve toward an increase in catalytic diversity. Phylogenetic analysis, overview. ENDO3 is the only nuclease, of all members of this family, that demonstrates activity characteristic of fungal S1-type nucleases and mung bean plant nuclease, i.e. it digests ssDNA under acidic pH and in the presence of Zn2+ |
730587 |
| 3.1.30.1 | more |
mode of nuclease action and molecular modeling, overview |
718072 |
| 3.1.30.1 | physiological function |
plant S1-like nucleases are the main class of enzymes involved in nucleic acid degradation during plant programmed cell death |
730587 |
| 3.1.30.1 | physiological function |
the S1 nuclease has an important function in DNA transcription, replication, recombination, and repair |
728950 |
| 3.1.30.1 | physiological function |
tight correlation found between the extracellular endonuclease activity and the rate of thymidine uptake by actively growing cells suggesting that this nuclease is required for fulfilling the nucleotide pool of precursors of DNA biosynthesis during the transformation of hyphae into the aerial mycelium and conidia in stressful environmental conditions |
718072 |
