Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 25 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction apoptosis in MDA-MB-231 cells is increased in SHIP2-depleted cells as compared to control cells 751180
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction cell adhesion to collagen-I-coated dishes is decreased in SHIP2-deicient MEF cells compared with wild type cells 714946
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction depletion of SHIP 5'-phosphatases increases neutrophil wound attraction and random motility through a PI3K-dependent pathway. Ectopic expression of the SHIP1 phosphatase domain impairs neutrophil migration 732045
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction disruption of the enzyme-Mena interaction in cancer cells leads to attenuated capacity for extracellular matrix degradation and invasion in vitro, as well as reduced metastasis in vivo 751174
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction enzyme deficiency leads to myeloproliferation and B-cell lymphoma in mice 751768
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction enzyme depletion inhibits cell migration of glioblastoma cells 751179
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction enzyme mutations are associated with opsismodysplasia. Mice expressing a germline catalytically inactive SHIP2 mutant protein are viable, but have defects in the development of muscle, adipose tissue and the female genital tract, as well as in somatic growth 750315
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86malfunction isoform SHIP2 inhibition or knockdown inhibits cell migration and reduces phosphorylated protein kinase B levels, resulting in sensitivity to chemotherapeutics 751770
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86metabolism the enzyme participates in the insulin signalling pathway in vivo 679146
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.86physiological function high glucose induces SHIP2 mRNA and protein levels in HepG2 cells. Overexpression of a dominant negative mutant SHIP2 ameliorates high glucose-induced de novo lipogenesis and secretion of apoB containing lipoprotein in HepG2 cells. Overexpression of the SHIP2 dominant negative mutant decreases high glucose-induced apoB containing lipoproteins secretion via reduction in reactive oxygen species generation, JNK phosphorylation and Akt activation. AMPK/mTOR/SREBP1 is the signaling pathway that mediates the effects of SHIP2 modulation on hepatic de novo lipogenesis 750611
Results 1 - 10 of 25 > >>