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Results 1 - 6 of 6
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.6more ecto-3'-nucleotidase activity is 60fold higher than that of ecto-5'-nucleotidase in Leishmania amazonensis. Additionally, ecto-3'-nucleotidase activity is 2fold higher in virulent Leishmania amazonensis cells than in avirulent ones 714930
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.6more macrophage-parasite interaction increases by 45% when the organism is grown at low phosphate concentration, as compared to the parasites grown in the presence of high phosphate concentrations, macrophages from female BALB/c mice -, 714928
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.6physiological function 3'-nucleotidase activity modulated by external stimuli, e.g. phosphate concentration, are involved in parasite-macrophage interaction -, 714928
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.6physiological function enzyme displays higher activity in parasites cultured in low phosphate medium. Both promastigotes grown in low or high phosphate medium are capable of inducing the release of neutrophil extracellular traps from human neutrophils in a dose- and time-dependent manner. Parasites grown in low phosphate have 2.4 times higher survival rate than high phosphate promastigotes. Neutrophil extracellular traps disruption is prevented by the treatment of the parasites with inhibitor ammonium tetrathiomolybdate. Inhibition of the enzyme by 3'-AMP, 5'-GMP, or ammonium tetrathiomolybdate decreases promastigote survival upon interaction with neutrophils 729823
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.6physiological function La3'-nucleotidase plays a significant role in the generation of adenosine, which contribute to mammalian host immune response impairment and establishment of infection, possible involvement of ecto-3'-nucleotidase in cellular adhesion 714930
Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.6physiological function the enzyme plays a role in parasite escape from neutrophil extracellular traps, one of the first mechanisms of the host immune system for preventing infection 750492
Results 1 - 6 of 6