EC Number   |
General Information |
Reference |
|---|
   3.1.21.2 | malfunction |
phenotype with reduced DNA repair activity of enzyme-deficient mutant strain BW527, overview |
-, 709173 |
| 3.1.21.2 | metabolism |
the presence of this enzyme, which is part of the DNA base excision repair pathway, suggests that thermophiles use a mechanism similar to that used by mesophiles to deal with the large number of abasic sites that arise in their chromosomes due to the increased rates of DNA damage at elevated temperatures |
-, 748070 |
| 3.1.21.2 | more |
a protruding loop containing a nuclease-associated modular domain 3 element is likely to be involved in substrate binding, as well as residues forming a separate nucleic acid binding surface adjacent to the active site. EndoII may bind its substrate inefficiently across the two sites in the dimer, offering a plausible explanation for the catalytic preponderance of single-strand nicks |
715906 |
| 3.1.21.2 | more |
Nfo catalyzed nucleotide incision and 3'-5' exonuclease activities are genetically coupled. modeling of nucleotide incision coupled to 3'-5' exonuclease activity preventing formation of lethal double-strand breaks when repairing bi-stranded clustered DNA damage, overview |
-, 716298 |
| 3.1.21.2 | physiological function |
endonuclease IV is the main base excision repair enzyme involved in DNA damage induced by UVA radiation and stannous chloride |
-, 709173 |
| 3.1.21.2 | physiological function |
endonuclease IV recognizes and cleaves DNA on the 5' side of various oxidatively damaged bases via nucleotide incision repair (NIR) |
-, 709173 |
| 3.1.21.2 | physiological function |
in the nucleotide incision repair pathway, an apurinic/apyrimidinic endonuclease incises duplex DNA 5' next to oxidatively damaged nucleotide. The multifunctional Escherichia coli endonuclease IV is involved in both base excision repair and nucleotide incision repair pathways, overview |
-, 716298 |
| 3.1.21.2 | physiological function |
in vitro endonuclease activity of the Escherichia coli McrA homologue that specifically cleaves S-modified DNA |
-, 716663 |
| 3.1.21.2 | physiological function |
key enzyme involved in the repair of abasic sites and DNA strand breaks |
-, 750388 |
| 3.1.21.2 | physiological function |
the enzyme plays a crucial role in defense against oxidative stress |
-, 730742 |
