EC Number   |
General Information |
Reference |
|---|
   3.1.13.5 | evolution |
TbRND shares sequence similarity with RNase D family enzymes but differs from all reported members of this family in possessing a CCHC zinc finger domain |
-, 715578 |
| 3.1.13.5 | malfunction |
TbRND depletion results in gRNA tails extended by 2-3 nucleotides on average. Second, overexpression of wild-type but not catalytically inactive TbRND results in a substantial decrease in the total gRNA population and a consequent inhibition of RNA editing. The observed effects on the gRNA population are specific as rRNAs, which are also 3'-uridylated, are unaffected by TbRND depletion or overexpression, phenotypes, overview |
-, 715578 |
| 3.1.13.5 | physiological function |
TbRND functions in guide RNA metabolism in vivo, TbRND is a 3' to 5' exoribonuclease that functions highly specific to the mitochondrion of trypanosomes. In vitro, TbRND exhibits 3' to 5' exoribonuclease activity, with specificity toward uridine homopolymers, including the 3' oligo(U) tails of guide RNAs that provide the sequence information for RNA editing |
-, 715578 |
