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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 3.1.1.90evolution it is likely that the two novel homologues of RPE65 (13cIMH and RPE65c, EC 3.1.1.90 and EC 3.1.1.64, respectively) are generated through gene duplication after the separation of fish RPE65 from the ancestral RPE65, because they exhibit an extremely high level of sequence identity (97%) and are located in the same chromosome, but on a different chromosome from RPE65 729213
Display the reaction diagram Show all sequences 3.1.1.90more key residues determining the isomerization product specificity of the enzyme are Tyr58, Phe103, and Leu133 729213
Display the reaction diagram Show all sequences 3.1.1.90physiological function the enzyme plays a key role in the generation of 13-cis retinoic acid, as well as in the modulation of neuronal functions in the brain 714991
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