EC Number   |
General Information |
Reference |
|---|
    3.1.1.79 | evolution |
archaeon Sulfolobus solfataricus P1 carboxylesterase is a thermostable enzyme belonging to the mammalian hormone-sensitive lipase (HSL) family. Enzyme SsoP1Est belongs to the HSL family exhibiting a classic alpha/beta hydrolase fold by sequence alignment with homologous esterases, which were well characterized in the structure. Thus, it contains a typical catalytic triad of esterases, which is expected to be composed of Ser151, Asp244, and His274, and another typical oxyanion hole, which is presumed to be composed of Gly80, Gly81, and Ala152 |
-, 750177 |
| 3.1.1.79 | evolution |
Lip1 is a family class 3 lipase. Family class 3 lipases are specific for mono- and diacylglycerols, but exhibit no regioselective production of diacylglycerols, in Malassezia globosa only LIP family lipases show activity on triacylglycerides. Comparisons of sequences and structures of Malassezia globosa lipases, overview |
-, 751503 |
| 3.1.1.79 | evolution |
Lip1 is a family class LIP lipase. Family class 3 lipases are specific for mono- and diacylglycerols, but exhibit no regioselective production of diacylglycerols, in Malassezia globosa only LIP family lipases show activity on triacylglycerides. Comparisons of sequences and structures of Malassezia globosa lipases, overview |
-, 751503 |
| 3.1.1.79 | evolution |
phylogentic analysis suggests that the two HSL isozymes derive from paralogous genes that may have arisen during a teleost-specific genome duplication event |
714766 |
| 3.1.1.79 | evolution |
the enzyme is a metagenome-derived member of the hormone-sensitive lipase family of lipolytic enzymes |
750161 |
| 3.1.1.79 | malfunction |
depletion of the enzyme affects lipoprotein-derived cellular cholesterol influx, diminishes the supply of cholesterol to the mitochondria, and results in the repression of steroidogenic acute regulatory protein and phospho-steroidogenic acute regulatory protein levels |
-, 730033 |
| 3.1.1.79 | malfunction |
enzyme expression is abolished in the slit-skin smear specimens from patients with lepromatous and borderline leprosy caused by Mycobacterium leprae, which suppresses lipid degradation through inhibition of enzyme expression |
730333 |
| 3.1.1.79 | malfunction |
enzyme-deficient mice accumulate sn-1,3-diacylglycerol and sn-2,3-diacylglycerol in white adipose tissue |
-, 730002 |
| 3.1.1.79 | malfunction |
in male mice, deficiency of hormone sensitive lipase causes deficient spermatogenesis, azoospermia, and infertility |
729643 |
| 3.1.1.79 | more |
catalytic residues are Asp28 and His281 |
-, 751503 |
