EC Number   |
General Information |
Reference |
|---|
    2.8.4.1 | evolution |
analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor |
761975 |
| 2.8.4.1 | evolution |
analysis of mcr-containing archaeal metagenome-assembled genomes (MAGs) from several hot springs, phylogenetic analysis, and evolution of methyl-coenzyme M reductase-containing hot spring Archaea, overview. A hydrothermal origin for these microorganisms is predicted based on optimal growth temperature predictions. Methane/alkane oxidation or methanogenesis at high temperature likely existed in a common archaeal ancestor. Five mcr-containing MAGs are identified as Verstraetearchaeota |
761975 |
| 2.8.4.1 | evolution |
the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview |
762442 |
| 2.8.4.1 | evolution |
the number of archaeal clades encoding the MCR continues to grow, suggesting that this complex is inherited from an ancient ancestor, or has undergone extensive horizontal gene transfer, detailed phylogenetic analysis and tree, overview. Candidatus Polytropus marinifundus gen. nov. sp. nov. encodes two divergent McrABG operons similar to those found in Candidatus Bathyarchaeota and Candidatus Syntrophoarchaeum metagenome-assembled genomes (MAGs). The Ca. P. marinifundus MCR operons are horizontally transferred |
761328 |
| 2.8.4.1 | malfunction |
growth defects associated with loss of the McrA thioglycine modification. The DELTAycaO-tfuA mutant lacks the McrA Gly465 thioamide |
-, 756576 |
| 2.8.4.1 | malfunction |
methylation mutant Mko4551 shows impaired growth under stress conditions |
-, 762454 |
| 2.8.4.1 | metabolism |
MCR catalyzes the terminal step in the formation of biological methane from methyl-coenzyme M and coenzyme B |
702287 |
| 2.8.4.1 | metabolism |
MCR is the terminal enzyme in methanogenesis (or the first in anaerobic methane oxidation, AOM) and is responsible for the release of methane. Unlike in methanotrophic archaea, Candidatus Argoarchaeum ethanivorans contains a homologue of N5, N10-methylenetetrahydromethanopterin reductase (Mer) and the membrane-associated heterodisulfide reductase. In particular, the heterodisulfide reductase makes it possible for the MCR reaction to be reversible, allowing for the anaerobic oxidation of methane and other short-chain alkanes |
760604 |
| 2.8.4.1 | metabolism |
methyl coenzyme M reductase (MCR) is a complex enzyme that catalyzes the final step in biological methanogenesis. The methyl coenzyme M reductase (MCR) is central to all methanogenic pathways. Whether or not methane is formed from CO2, methyl groups, or acetate, the final step is catalyzed by MCR. In this reaction, methyl coenzyme M (CH3-S-CoM) is reduced by the thiol coenzyme B (HS-CoB) to form methane and the mixed disulfide (also called heterodisulfide, CoM-S-S-CoB). MCR is also involved in the anaerobic oxidation of methane |
-, 761395 |
| 2.8.4.1 | metabolism |
overview of metabolic potentials in mcr-containing MAGs |
761975 |
