EC Number   |
General Information |
Reference |
|---|
    2.8.1.2 | malfunction |
3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors with an increase in serotonin level in the prefrontal cortex, but not with abnormal morphological changes in the brain |
739651 |
| 2.8.1.2 | malfunction |
mercaptolactate-cysteine disulfiduria is caused by enzyme defect with or without mental retardation |
723958 |
| 2.8.1.2 | metabolism |
3MST produces Cys-SSH and GSSH together with the potential signaling molecules hydrogen per- and tri-sulfide (H2S2 and H2S3). Cys-SSH and GSSH are produced in the brain of wild-type mice but not in those of 3MST-KO mice. The levels of total persulfurated species in the brain of 3MST-KO mice are less than 50% of that in the brain of wild-type mice. Cys-SSH and GSSH are produced in the presence of physiological concentrations of cysteine and glutathione, while those with longer sulfur chains, Cys-SSnH and GSSnH, are produced in the presence of lower than physiological concentrations of cysteine and glutathione |
762422 |
| 2.8.1.2 | metabolism |
a mitochondrial sulfur catabolic pathway catalyzes the complete oxidation of L-cysteine to pyruvate and thiosulfate. After transamination to 3-mercaptopyruvate, the sulfhydryl group from L-cysteine is transferred to glutathione by sulfurtransferase Str1 and oxidized to sulfite by the sulfur dioxygenase Ethe1. Sulfite is then converted to thiosulfate by addition of a second persulfide group by sulfurtransferase 1. This pathway is most relevant during early embryo development and for vegetative growth under light-limiting conditions |
762111 |
| 2.8.1.2 | metabolism |
the enzyme functions as an antioxidant protein and can produce H2S (or HS2) and SOx |
739651 |
| 2.8.1.2 | metabolism |
the enzyme interacts with proteins involved in Moco and FeS cluster biosynthesis like L-cysteine desulfurase NFS1 and the rhodanese-like protein MOCS3 |
738634 |
| 2.8.1.2 | metabolism |
the enzyme is, together with cysteine aminotransferase, primarily responsible for H2S production in peripheral neurons |
738896 |
| 2.8.1.2 | metabolism |
the first step of sulfur transfer that leads to pyruvate release and formation of the persulfide intermediate is very efficient. It critically depends on the electrostatic contribution provided by the CGSGVT catalytic loop, any role of the so-called Ser/His/Asp triad can be excluded. In a concerted mechanism, the water-mediated protonation of the pyruvate enolate and S0 transfer from the deprotonated 3-mercaptopyruvate to the thiolate form of the catalytic cysteine occur concomitantly |
-, 760250 |
| 2.8.1.2 | physiological function |
3-mercaptopyruvate sulfurtransferase coupled with cysteine (aspartate) aminotransferase is responsible for the production of H2S in the vascular endothelium of the thoracic aorta |
738198 |
| 2.8.1.2 | physiological function |
3MST and cytosolic and mitochondrial cysteine aminotransferases are localized to endothelial cells of the thoracic aorta and together enzymes produce H2S in this cell type. H2S is a smooth muscle relaxant released from endothelium |
704359 |
