EC Number   |
General Information |
Reference |
|---|
    2.7.8.24 | malfunction |
a deletion mutant is much more sensitive than the wild type strain when challenged with Al3+ and tetradecyltrimethylammonium bromide, and shows a significant loss of viability |
-, 723125 |
| 2.7.8.24 | metabolism |
the enzyme is responsible for the synthesis of phosphatidylcholine, which acts as a temporary reservoir for Al3+ |
-, 723125 |
| 2.7.8.24 | metabolism |
the phosphatidylcholine synthase pathway is the primary pathway for synthesis of phosphatidylcholine in Legionelly dumoffii. Choline is condensed directly with CDP-diacylglyceride to form phosphatidylcholine in a reaction catalyzed by a bacterium-specific Pcs enzyme |
738417 |
| 2.7.8.24 | more |
cytoplasmic loop between the second and third membrane helix contains the majority of the conserved amino acids of a CDP-alcohol phosphotransferase motif (DGX2ARX12GX3DX3D), crucial role of this motif in choline binding and enzyme activity |
-, 738208 |
| 2.7.8.24 | physiological function |
phosphatidylcholine, produced by the enzyme, is essential for the expression of virulence-related genes that is controlled by the two-component system VirA/G |
-, 738208 |
| 2.7.8.24 | physiological function |
the enzyme synthesizes phosphatidylcholine, a membrane-forming phospholipid, via the phosphatidylcholine synthase pathway, Pcs. Structurally different PC species are distributed in the outer and inner membranes |
738417 |
