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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16evolution the majority of primases are classified into two major groups, that is, the bacterial DnaG-type primases and the more complex eukaryotic primases. Archaea encode both types of DNA primase, they encode a eukaryotic-type primase comprising a catalytic subunit (PriS) and a noncatalytic subunit (PriL). Identification of a primase noncatalytic subunit, termed PriX, from the hyperthermophilic archaeon Sulfolobus solfataricus. Phylogenomic analysis, overview 739147
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16metabolism helicase is not essential but accelerates the reaction. HelpTN2 is a helicase of the SF1 family also encoded by pTN2 who enhances the PolpTN2-primed synthesis of dsDNA by PolB using M13mp18 as a template 738189
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16more the catalytic activity of PriS is modulated through concerted interactions with the two noncatalytic subunits in primer synthesis. The catalytic activity of PriS is modulated through concerted interactions with the two noncatalytic subunits in primer synthesis. PriX subunit residues 26-54 are in a flexible region. PriX residues 55-154 fold into a single domain containing 6 helices, which form a compact core stabilized by extensive hydrophobic interactions. The overall structure of the PriX protein is quite unique 739147
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16physiological function at the initiation of chromosomal DNA replication, DNA primases synthesize short RNA primers, which are subsequently elongated by DNA polymerases 719757
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16physiological function DNA primase PolpTN2 and DNA polymerase PolB are essential for synthesis of dsDNA from deoxynucleotide triphosphates by producing an oligonucleotide primer. The first step of template-free DNA synthesis may involve the creation of seeds by PolpTN2 primase, which are subsequently amplified in synergy with PolB. Template?free synthesis is highly temperature?dependent 738189
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16physiological function DNA primases play a critical role in the initiation of DNA replication by synthesizing RNA primers on both the leading and lagging strands since DNA polymerases are incapable of de novo DNA synthesis. Product synthesis by PriSL in the presence of PriX, the Sso0502 product, is over an order of magnitude (about 16fold) more efficient than that in its absence. PriX and PriL bind template DNA differently. Both PriSX and PriSLX differ from PriSL in primer synthesis, overview. PriL but not PriX enhances primer extension by PriS 739147
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.B16physiological function the heterodimeric primase complex is necessary for archaeal survival 720231
Results 1 - 7 of 7