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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64evolution phylogenetic analysis 721524
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64malfunction A knock-out of the USP gene results in non-fertile pollen. Mutant plants show an arabinose reduction in the cell wall, and accumulate mainly two sugars, arabinose and xylose, in the cytoplasm 726176
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64malfunction inactivation of the two parasite diphosphorylases UGP and USP, results in parasite death 761959
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64metabolism Leishmania parasites possess a UDP-sugar pyrophosphorylase (USP), which has broad substrate specificity and is involved in monosaccharide salvage 761959
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64metabolism the enzyme, likely involved in monosaccharide salvage, preferentially generates UDP-glucose and UDP-galactose, but it may also activate other hexose- or pentose-1-phosphates such as galacturonic acid-1-phosphate or arabinose-1-phosphate 722975
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64metabolism UDP-sugar pyrophosphorylases are involved in the plant salvage pathways 761567
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64more active site conformations of apoenzyme and ligand-bound enzyme, substrate binding structures, structure-function analysis, modeling, overview 722975
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64physiological function enzyme is able to complement an Escherichia coli GalU mutant 738819
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64physiological function gene silencing of USP by miRNA causes a concomitant reduction of USP and of glucuronokinase activity presumably to prevent the accumulation of sugar-1-phosphates interfering with normal metabolism and depleting the phosphate pool of the cell 739372
Display the word mapDisplay the reaction diagram Show all sequences 2.7.7.64physiological function Leishmania parasites express a UDP-sugar pyrophosphorylase (USP) responsible for monosaccharides salvage that is able to generate both UDP-Gal and UDP-Glc. In vitro, Leishmania USP preferentially uses UTP as a nucleotide donor, and can activate a variety of sugar-1-phosphates. The enzyme is most active with galactose 1-phosphate and glucose 1-phosphate, with a slight preference for the former, but it cannot activate N-acetylated sugars. UDP-sugar-producing diphosphorylases catalyze reversible reactions, require magnesium for catalysis, and act through an ordered sequential Bi-Bi reaction mechanism. In the forward reaction, UTP binds before the sugar 1-phosphate, and after catalysis, inorganic diphosphate is released before the UDP-sugar 761959
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