EC Number   |
General Information |
Reference |
|---|
   2.7.7.50 | malfunction |
enzyme knockdown impairs wing development and represses Hedgehog pathway signalling activity. Enzyme knockdown downregulates transcription factor Cubitus interruptus but upregulates smoothend protein levels |
762433 |
| 2.7.7.50 | metabolism |
the enzyme is essential for viral mRNA cap formation |
-, 762509 |
| 2.7.7.50 | metabolism |
the enzyme regulates Hedgehog pathway signaling activity depending on its capping-enzyme activity in the cytoplasm and through antagonizing protein kinase A |
762433 |
| 2.7.7.50 | physiological function |
a disruptive mutation in the polypeptide Spt5 C-terminal domain-binding site of GTase is synthetically lethal with mutations in the polymerase Pol2 C-terminal domain-binding site. C-terminal domain phosphorylation has opposite effects on the interaction of GTase with Pol2 (Ser5-PO4 is required for binding) versus Spt5 (Thr1-PO4 inhibits binding) |
-, 738327 |
| 2.7.7.50 | physiological function |
in Dts36, a temperature sensitive virus mutant affecting the large subunit of the capping enzyme, of the three enzymatic activities required for mRNA capping, the guanylyltransferase and methyltransferase activities are compromised while the triphosphatase activity and the D12 subunit interaction are unaffected. The mutant enzyme is also defective in stimulating early gene transcription termination and intermediate gene transcription initiation in vitro |
-, 739747 |
| 2.7.7.50 | physiological function |
RNA triphosphatase Cet1 and the RNA guanylyltransferase Ceg1 interact to form a mRNA capping enzyme complex. The guanylyltransferase activity of Ceg1 is stimulated by binding with Cet1. RNA trisphosphatase Cet1 is responsible for transport of Ceg1 into the nucleus, while triphosphatase activity of Cet1 is not required. The Cet1 223-549 region is sufficient for nuclear localization of Cet1 |
-, 739487 |
