EC Number   |
General Information |
Reference |
|---|
    2.7.7.13 | evolution |
four members of GMP gene family are encoded in the tomato genome, which constitutively expressed in various tissues in distinct expression patterns |
739463 |
| 2.7.7.13 | evolution |
the enzyme belongs to the mannose-6-phosphate isomerase type 2 family |
-, 733811 |
| 2.7.7.13 | evolution |
unrooted relationship tree of MPG proteins from various organisms, phylogenetic analysis, overview |
723440 |
| 2.7.7.13 | malfunction |
enzyme deficiency leads to reduced alpha-dystroglycan glycosylation in the muscle biopsies of affected individuals and in available fibroblasts. Mutations in GDP-mannose pyrophosphorylase B (GMPPB) can result in muscular dystrophy variants with hypoglycosylated alpha-dystroglycan. Overexpression of wild-type GMPPB in fibroblasts from an affected individual partially restores glycosylation of alpha-dystroglycan in muscle. Five of the identified missense mutations cause formation of aggregates in the cytoplasm or near membrane protrusions. Enzyme mutant phenotypes with brain and muscle abnormalities, overview |
737417 |
| 2.7.7.13 | malfunction |
overexpression of OsVTC1-8 does not restore the ascorbic acid synthesis of the vtc1-1 mutant in Arabidopsis |
739330 |
| 2.7.7.13 | malfunction |
reducing ascorbic acid leads to leaf lesion and defence response in knock-down of the ascorbic acid biosynthetic enzyme GDP-D-mannose pyrophosphorylase gene in tomato plant. Constitutive overexpression of SlGMP3 increases the total ascorbic acid contents in the fully expanded leaves and red ripe fruits, with enhanced tolerance to oxidative stress in SlGMP3 overexpressing plants. In SlGMP2/3-knockdown lines, the total ascorbic acid contents in leaves, immature green fruits, and breaker fruits decrease dramatically. With the developments of fruit, the ascorbic acid levels increase up to 46% in breaker stage compared with immature green stage in wild-type plants, whereas no major difference is observed between two stages of SlGMP2/3-knockdown lines. In SlGMP2/3-knockdown transgenic line KD17, SlGME2 and SlGGP1 are significantly up-regulated (over one fold) compared with the wild-type plants. The spontaneous lesions on the leaves of SlGMP2/3-knockdown plants develop in a similar manner as a hypersensitive response after pathogen attack. Impairment of the photosynthetic system in SlGMP2/3-knockdown plants, overview |
739463 |
| 2.7.7.13 | malfunction |
the ascorbic acid-deficient Arabidopsis thaliana mutant vtc1-1 is defective in GDP-mannose pyrophosphorylase and exhibits conditional hypersensitivity to ammonium, a phenomenon that is independent of ascorbic acid deficiency. Defective N-glycosylation in vtc1-1 contributes to cell wall, membrane and cell cycle defects, resulting in root growth inhibition in the presence of NH4+, GDP-mannose deficiency does not generally lead to and is not the primary cause of NH4+ sensitivity. GDP-mannose deficiency results in an up-regulation of ER stress genes, enhanced programmed cell death and defective cell cycle proliferation in vtc1-1 triggered by NH4+, overview. Root development in the presence of NH4+ is fully recovered in vtc1-1 containing one wild-type copy of VTC1 |
-, 723381 |
| 2.7.7.13 | malfunction |
the lack of a functional bceA gene does not affect exopolysaccharide production yield in a non-polar insertion bceA mutant. The in silico search for putative bceA homologues reveals the presence of 2-5 bceA orthologues in the Burkholderia genomes available. This suggests that in Burkholderia cepacia IST408 putative bceA functional homologues may compensate the bceA mutation |
-, 746961 |
| 2.7.7.13 | metabolism |
enzyme OsVTC1-1 and OsVTC1-3 have higher GMPase activities than enzyme OsVTC1-8 in vitro. Only OsVTC1-1 and OsVTC1-3 are involved in ascorbic acid synthesis in rice |
739330 |
| 2.7.7.13 | metabolism |
GDP-mannose pyrophosphorylase which catalyzes the conversion of D-mannose-1-P to GDP-D-mannose in AsA biosynthetic pathway. GDP-D-mannose pyrophosphorylase is a vital enzyme in the Smirnoff-Wheeler's pathway for the biosynthesis of ascorbic acid in plants |
739463 |
