EC Number   |
General Information |
Reference |
|---|
    2.7.4.8 | drug target |
success for treatment with 5'-guanylic acid in conjunction first-line antileishmanial therapies |
761201 |
| 2.7.4.8 | evolution |
DLG1 is a member of the membrane associated guanylate kinase (MAGUK) family of proteins. The GK domains of the MAGUK family proteins are catalytically inactive, and instead are involved in protein-protein interactions |
737590 |
| 2.7.4.8 | evolution |
GMPK is a member of the family of ATP:NMP phosphoryltransferases, nucleoside monophosphate kinases, NMP kinases, or NMPKs |
738145 |
| 2.7.4.8 | malfunction |
removal of membrane-associated guanylate kinase (MAGUK) via RNAi-mediated knockdown in the CA1 hippocampal region in immature animals causes rapid and lasting reductions in glutamatergic transmission. In mature animals, the same manipulation has little acute effect. The hippocampal dentate gyrus, a region with ongoing adult neurogenesis, is sensitive to MAGUK loss in mature animals, behaving like an immature CA1 cell |
761735 |
| 2.7.4.8 | metabolism |
critical role in metabolic activation of antiviral and antineoplastic nucleoside-analog prodrugs |
761496 |
| 2.7.4.8 | metabolism |
guanylate kinase is a key enzyme in guanine nucleotide biosynthesis, purine biosynthetic pathways in plant cells and bacteria, overview |
-, 738614 |
| 2.7.4.8 | metabolism |
guanylate kinase is a key enzyme in guanine nucleotide biosynthesis, purine biosynthetic pathways in plant cells and bacteria, overview. Accumulation of guanosine 3',5'-bisdiphosphate has little effect on the guanine nucleotide profile of Escherichia coli |
738614 |
| 2.7.4.8 | metabolism |
guanylate kinase is one of the key enzymes in nucleotide biosynthesis |
761281 |
| 2.7.4.8 | metabolism |
the enzyme catalyzes the transfer of a phosphate from ATP to GMP. It is indispensable for converting GMP to GDP and therefore synthesis of GTP |
761155 |
| 2.7.4.8 | metabolism |
the only known enzyme responsible for cellular GDP production, making it essential for cellular viability and proliferation |
761496 |
