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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.10malfunction in HEK-293 cells, RNA inter ference (RNAi) directed against AK4 inhibits proliferation and promotes death. RNAi directed against AK4 inhibits cell proliferation and causes death in both cell types, HEK-293 and Hep-G2, although cell cycle parameters are affected only in Hep-G2 cells. Reductions of AK4 levels are always associated with cell death 737551
Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.10physiological function adenylate kinase isozyme 4 belongs to a family of nucleotide monophosphate kinases involved in energy metabolism. Enzyme AK4 play a role in protection from stress. In HEK-293 cells, hypoxia increases AK4 expression but does not affect proliferation or viability. Hep-G2 cells show much higher AK4 levels, which decrease under hypoxia along with markedly reduced cell proliferation and increased cell death. AK4-mediated stress protection is not limited to one particular death scenario 737551
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