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2.7.11.14
malfunction
a mouse line RKS561L is generated in which GRK1 is overexpressed (S56L mutant cDNA is used). Overexpressed GRK1 in RKS561L mice is located in the outer segment and greatly accelerates the rate of rhodopsin phosphorylation. Transgenic mice show that the light response amplitude is only modestly diminished, but the exponential decay constant of the response (tau REC) and the limiting time constant (tau D) are both highly significantly accelerated. It is concluded that GRK1 and recoverin, in addition to their role in phosphorylating rhodopsin, may also regulate light-activated phosphodiesterase decay and mediate the increase in temporal resolution of rods during light adaptation
725771
2.7.11.14
physiological function
the Ca2+-dependent regulation of the enzyme by recoverin modulates the decay of light-activated phosphodiesterase. This modulation is responsible for acceleration of response decay and the increase in temporal resolution of rods in background light
738776
2.7.11.14
physiological function
the enzyme is required for the timely inactivation of mouse cone photoresponse
738675
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