EC Number   |
General Information |
Reference |
|---|
    2.7.1.58 | evolution |
the enzyme belongs to the ASKHA (acetate and sugar kinases/hsc70/actin) family of phosphotransferases, ASKHA signature motifs in KDGal kinase, overview |
-, 721158 |
| 2.7.1.58 | malfunction |
growth studies with knock-out mutants indicate the functional involvement of galactose dehydrogenase, galactonate dehydratase, and KDPGal aldolase in D-galactose degradation |
-, 759203 |
| 2.7.1.58 | malfunction |
the deletion mutant does not grow on D-galactose |
-, 759203 |
| 2.7.1.58 | metabolism |
a cluster of genes encoding putative enzymes of the DeLey-Doudoroff pathway for D-galactose degradation including galactose dehydrogenase, galactonate dehydratase, 2-keto-3-deoxygalactonate kinase and 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) aldolase is involved in D-galactose degradation. The transcriptional regulator GacR is an activator of genes of the DeLey-Doudoroff pathway |
-, 759203 |
| 2.7.1.58 | metabolism |
the 2-oxo-3-deoxygalactonate kinase catalyzes the penultimate step of an alternative route of D-galactose assimilation, the so-called De Ley-Doudoroff pathway, in which D-galactose is metabolized into pyruvate and D-glyceraldehyde 3-phosphate in five consecutive reactions carried out by specific enzymes. The pathway involves the phosphorylation of 2-oxo-3-deoxygalactonate to 2-oxo-3-deoxygalactonate 6-phosphate catalyzed by the enzyme with ATP serving as a phosphoryl-group donor. Comparison with other D-galactose metabolic pathways, overview. 2-oxo-3-deoxygalactonate 6-phosphate decomposes into puruvate and D-glyceraldehyde 3-phosphate, both products are utilized by the glycolytic pathway |
-, 721158 |
| 2.7.1.58 | metabolism |
the enzyme is part of the De Ley-Doudoroff pathway |
-, 759203 |
| 2.7.1.58 | more |
the putative substrate-binding site is created mostly by the N-terminal domain, substrate binding includes the conserved Tyr78 from loop L6, His141 and Lys143 from L15, as well as Glu119 from the H4 helix, nucleotide-binding site structure, overview |
-, 721158 |
| 2.7.1.58 | physiological function |
the enzyme is required for D-galactose degradation via the DeLey-Doudoroff pathway in the domain of archaea |
-, 759203 |
