EC Number   |
General Information |
Reference |
|---|
    2.7.1.25 | evolution |
the MXAN3487 protein displays sequence and structural homology to adenosine 5'-phosphosulfate (APS) kinase family members and contains putative motifs for ATP and APS binding |
-, 759740 |
| 2.7.1.25 | malfunction |
deletion of gene MXAN3487 significantly delays fruiting body formation and the production of McuA, a spore coat protein secreted by the Myxococcus xanthus Mcu CU system. Delayed expression of mcuABC in DELTAMXAN3487 may be secondary to a cell aggregation defect |
-, 759740 |
| 2.7.1.25 | malfunction |
the apk1 apk3 apk4 triple mutant combination is pollen lethal |
722260 |
| 2.7.1.25 | metabolism |
APS kinase catalyses the second reaction in the two-step conversion of inorganic sulphate to 3'-phosphoadenosine 5'-phosphosulfate (PAPS). MXAN3487 is not regulated by sulfur starvation |
-, 759740 |
| 2.7.1.25 | metabolism |
sulfate activation pathway |
705207 |
| 2.7.1.25 | more |
homology modeling of the APSK domain structure of EhAPSK using three structures as templates (PDB IDs: 3UIE, 4FXP, and 2GKS), overview. All combinations of the three predicted structures are calculated by visual molecular dynamics |
760013 |
| 2.7.1.25 | more |
MXAN3487 protein homology modeling |
-, 759740 |
| 2.7.1.25 | physiological function |
although the MXAN3487 locus is not linked to other sulfate assimilation genes, its protein product may have adenosine 5'-phosphosulfate (APS) kinase activity in vivo. The importance of the ATP-binding site for activity is demonstrated. MXAN3487 seems not to function in a reductive sulfate assimilation pathway. The enzyme may phosphorylate molecules structurally related to APS, generating metabolites necessary for Myxococcus xanthus development, and exerts a positive effect on the mcuABC operon whose expression is morphogenesis-dependent. The enzyme is a regulator for the timing of cell aggregation. Protein MXAN3487 is a bona fide APS kinase, the kinase activity of MXAN3487 protein is essential for its function. MXAN3487 is not regulated by sulfur starvation |
-, 759740 |
| 2.7.1.25 | physiological function |
in Arabidopsis thaliana, the enzyme is essential for reproductive viability |
723657 |
| 2.7.1.25 | physiological function |
the enzyme is essential for plant reproduction and viability |
722260 |
