EC Number   |
General Information |
Reference |
|---|
   2.7.1.173 | evolution |
the enzyme is structurally similar to Rossmann fold metabolite kinases |
718250 |
| 2.7.1.173 | malfunction |
in NRK1-silenced cells, both nicotinamide riboside- and NMN-mediated rescue from FK866-induced NAD+ depletion and cell death are potently and significantly reduced, overview |
739212 |
| 2.7.1.173 | metabolism |
distinct metabolic routes, starting from various precursors, are known to support NAD+ biosynthesis with tissue/cell-specific efficiencies, probably reflecting differential expression of the corresponding rate-limiting enzymes, i.e. nicotinamide phosphoribosyltransferase, quinolinate phosphoribosyltransferase, nicotinate phosphoribosyltransferase and nicotinamide riboside kinase |
738213 |
| 2.7.1.173 | metabolism |
in addition to the seven-component pyridine nucleotide cycle, an eight-component cycle involving nicotinate riboside kinase operates in plants. NaR kinase does not make a significant contribution to salvage for pyridine nucleotide synthesis |
718225 |
| 2.7.1.173 | metabolism |
nicotinamide riboside elevates NAD+ levels via the nicotinamide riboside kinase pathway and by a pathway initiated by splitting the nucleoside into a nicotinamide base followed by nicotinamide salvage. Yeast nicotinic acid riboside utilization largely depends on uridine hydrolase and nicotinamide riboside kinase, and nicotinic acid riboside bioavailability is increased by ester modification |
-, 698901 |
| 2.7.1.173 | metabolism |
the enzyme is involved in the eukaryotic nicotinamide riboside kinase, Nrk, pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to NAD+ by phosphorylation and adenylylation, overview. Nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage |
718250 |
| 2.7.1.173 | metabolism |
the enzyme is involved in the NAD+ biosynthesis pathway. In the initial step of the pathway, NRK activity catalyses the phosphorylation of nicotinamide riboside (NR) to nicotinamide mononucleotide (NMN), see for EC 2.7.1.22. Importance of different salvage pathways involved in metabolising the vitamin B3 class of NAD+ precursor molecules, with a particular focus on the nicotinamide riboside kinase pathway at both a tissue-specific and systemic level, regulation of the NRK enzymes, overview. Alternatively, NRK activity can phosphorylate nicotinic acid riboside (NaR) to nicotinic acid mononucleotide (NaMN) |
761705 |
| 2.7.1.173 | more |
comparison to the Nrk-independent utilization pathway of nicotinamide riboside in yeast, overview |
-, 698901 |
| 2.7.1.173 | more |
proposed NRK expression in disease and potential therapeutic interventions |
761705 |
| 2.7.1.173 | physiological function |
nicotinamide riboside is a relevant NAD+ precursor |
738213 |
