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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145evolution evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase 738781
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145more enzyme identification using a mutagenic nucleoside analogue 2-hydroxy-2'-deoxyadenosine 5'-monophosphate, overview. Method development and evaluation for in vivo evolution selection method for active deoxyribonucleoside kinase proteins, including selection of antibiotic-resistant colonies resulting frommutations by phosphorylated 2-hydroxy-deoxyadenosine and the subsequent isolation of the plasmid DNAs. Fifteen Dm-dNK mutants selected after the seventh and eighth evolutioncycles are actually active in vivo, one shows activity similar to the wild-typ enzyme 738739
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145more structure of non-TK1 like kinases, overview 738781
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145physiological function DmdNK is cell cycle regulated and under the control of cyclin E and the dE2F1 transcription factor, involved in G1/S phase transition 738781
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145physiological function dNK expression increases substantially sensitivity of cells to 5-aza-2'-deoxycytidine and 2'-deoxy-zebularine 703396
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145physiological function no differences between mutant cytosolic Dm-dNK, mitochondrial Dm-dNK, and wild-type nuclear Dm-dNK in regards to enzyme activity, cellular sensitivity to nucleoside analogues, or bystander cell killing. Tan IIA may influence the bystander effect of cancer cells expressing Dm-dNK by regulating the expression of Cx43 and Cx26. Tanshinone (Tan) IIA is a fat-soluble and pharmacologically active ingredient of Danshen, a traditional Chinese medicine used in the treatment of cardiovascular diseases. It is isolated from the rhizome of a Chinese herb Salvia miltiorrhiza. Tan IIA treatment of osteosarcoma cells results in the upregulation of Cx43 and Cx26 proteins 739211
Show all pathways known for 2.7.1.145Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.145physiological function the enzyme is involved in chloroplast development 762135
Results 1 - 7 of 7