EC Number   |
General Information |
Reference |
|---|
   2.6.1.109 | evolution |
8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) is found exclusively in marine bacteria of the genus Shewanella |
-, 734255 |
| 2.6.1.109 | malfunction |
creation of an Shewanella oneidensis kdnA/kdnB in-frame deletion strain shows increased sensitivity to the cationic antimicrobial peptide polymyxin as well as bile salts |
-, 734255 |
| 2.6.1.109 | metabolism |
8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis pathway, 8-dehydro-3-deoxy-D-manno-octulosonic acid is directly converted to Kdo8N followed by incorporation into lipid A, overview. The entire gene cluster is required for 8-amino-3,8-dideoxy-D-manno-octulosonic acid (Kdo8N) biosynthesis |
-, 734255 |
| 2.6.1.109 | metabolism |
typical LPS architecture is organized into three distinct regions, termed lipid A, core, and O-chain, respectively, each characterized by its own structure, biosynthesis, and function. The connection between the lipid A and the core oligosaccharide is held by a characteristic monosaccharide, 3-deoxy-D-manno-oct-2-ulosonic acid, i.e. Kdo |
-, 734519 |
| 2.6.1.109 | physiological function |
the first sugar bridging the hydrophobic lipid A and the polysaccharide domain is 3-deoxy-D-manno-octulosonic acid (Kdo), and thus it is critically important for lipopolysaccharide biosynthesis. KdnA is a pyridoxal 5'-phosphate-dependent aminotransferase that utilizes L-glutamate and may play a role in outer membrane integrity |
-, 734255 |
