EC Number   |
General Information |
Reference |
|---|
    2.6.1.100 | evolution |
BtrR has a fold characteristic of the aspartate aminotransferase family and is a member of the class of aminotransferases that function primarily in the biosynthesis of secondary metabolites, SMAT, i.e. the secondary metabolite aminotransferases subfamily |
723736 |
| 2.6.1.100 | malfunction |
disruption mutant strain HN4 is completey devoid of neomycin production |
721901 |
| 2.6.1.100 | metabolism |
Neo-6 is the enzyme catalysing the transamination of 2-deoxy-scyllo-inosose, DOI, using L-glutamine as an amino donor to produce 2-deoxyscyllo-inosamine as required for 2-deoxystreptamine biosynthesis. Neo-6 also catalyses the amino transfer from L-glutamine to 3-amino-2,3-dideoxy-scyllo-inosose to produce 2-deoxystrepamine, EC 2.6.1.101, the aglycon in neomycins, overview |
-, 663004 |
| 2.6.1.100 | metabolism |
the aminotransferase BtrR is involved in the biosynthesis of butirosin |
723736 |
| 2.6.1.100 | metabolism |
the enzyme catalyses the transamination of 2-deoxy-scyllo-inosose to give 2-deoxy-scyllo-inosamine, an intermediate in the biosynthesis of 2-deoxystreptamine, biosynthetic pathway of 2-deoxystreptamine, overview |
-, 722025 |
| 2.6.1.100 | metabolism |
the enzyme is involved in the biosynthesis of 2-deoxystreptamine (DOS)-containing aminoglycoside neomycin. NeoB also shows L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase activity resulting in formation of 2-deoxy-streptamine, EC 2.6.1.101 |
-, 719670 |
| 2.6.1.100 | metabolism |
the enzyme is involved in the biosynthesis of kanamycin |
-, 640131 |
| 2.6.1.100 | metabolism |
the enzyme is involved in the biosynthesis of neomycin |
-, 640131 |
| 2.6.1.100 | metabolism |
the enzyme is involved in the biosynthesis of ribostamycin |
-, 640131 |
| 2.6.1.100 | metabolism |
the enzyme is involved in tobramycin biosynthesis catalyzing the second step of the 2-deoxystreptamine biosynthetic pathway, 2-deoxystreptamine is a subunit of tobramycin, overview |
672584 |
