EC Number   |
General Information |
Reference |
|---|
    2.5.1.7 | drug target |
catalyzes the first step in the biosynthesis of the bacterial cell wall. This pathway is essential for the growth of bacteria but missing in mammals, that nominates MurA as an attractive antibacterial target |
759547 |
| 2.5.1.7 | drug target |
the lack of a counterparts in eukaryotes suggests the enzyme to be a promising drug target |
759352 |
| 2.5.1.7 | malfunction |
frame deletion of murAA leads to increased susceptibility of Enterococcus faecalis to the cephalosporins ceftriaxone and ceftazidime |
721303 |
| 2.5.1.7 | malfunction |
gram-negative bacteria have only one copy of the murA gene, its deletion is lethal |
706916 |
| 2.5.1.7 | metabolism |
the enzyme catalyzes the first committed step of peptidoglycan biosynthesis |
759343 |
| 2.5.1.7 | metabolism |
the enzyme catalyzes the first committed step of peptidoglycan biosynthesis. MurA is indispensable for cell integrity |
759352 |
| 2.5.1.7 | metabolism |
the enzyme catalyzes the first step in the biosynthesis of the bacterial cell wall |
759547 |
| 2.5.1.7 | metabolism |
the enzyme catalyzes the first step of peptidoglycan biosynthesis pathway which is essential in the bacterial cell wall composition |
-, 759095 |
| 2.5.1.7 | physiological function |
catalyzes the first committed step in peptidoglycan biosynthesis |
702267 |
| 2.5.1.7 | physiological function |
enzyme catalyzes the first committed step of bacterial cell wall biosynthesis |
706916 |
