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EC Number General Information Commentary Reference
Show all pathways known for 2.5.1.49Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.49physiological function wild-type cells are able to grow on both methanethiol and dimethyldisulfide as sole sulfur sources. Both sulfur compounds are incorporated as an entire molecule, adding the terminal S-CH3 group to O-acetylhomoserine. In this reaction, methionine is directly formed. the reaction is catalyzed by O-acetylhomoserine sulfhydrylase MetY. The deletion of metY results in methionine auxotrophic strains grown on methanethiol or dimethyldisulfide as sole sulfur sources. In vitro studies with the wild-type reveal a relatively low activity of MetY for methanethiol and dimethyldisulfide 722931
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