EC Number   |
General Information |
Reference |
|---|
   2.4.99.19 | evolution |
bacterial PglB and archaeal AglB constitute a protein family of the catalytic subunit of OST, along with STT3 from eukaryotes, that has three types of OST catalytic centers, structure analysis and comparison, overview |
-, 709145 |
| 2.4.99.19 | evolution |
eukaryotic and prokaryotic OTases catalyze the transfer of oligosaccharides by a conserved mechanism |
710405 |
| 2.4.99.19 | evolution |
in the delta proteobacteria Desulfovibrio sp., the PglB homologue is more closely related to eukaryotic and archaeal OTases than to its Campylobacter counterparts |
719566 |
| 2.4.99.19 | evolution |
sequence analysis using 28 homologs from evolutionarily distant organisms, relationship between PglB and other Stt3 proteins, detailed overview Several inter-transmembrane loop regions of PglB/Stt3 contain strictly conserved motifs that are essential for PglB function |
718913 |
| 2.4.99.19 | malfunction |
if the WWDYGY signature sequence is mutated to WAAYGY, PglB is no longer active in vivo |
673020 |
| 2.4.99.19 | malfunction |
insertional knockout mutagenesis of the gene pglB2 is unsuccessful, suggesting that it is essential |
-, 708941 |
| 2.4.99.19 | metabolism |
PglB is involved in the Campylobacter jejuni general N-linked protein glycosylation pathway, overview |
685156 |
| 2.4.99.19 | metabolism |
PglB is involved in the general N-linked glycosylation pathway encoded by the pgl gene cluster |
673020 |
| 2.4.99.19 | metabolism |
the central enzyme in N-linked glycosylation is the oligosaccharyl transferase PglB, which catalyzes glycan transfer from a polyprenyldiphosphate-linked carrier to select asparagines within acceptor proteins |
718913 |
| 2.4.99.19 | more |
several inter-transmembrane loop regions of PglB/Stt3 contain strictly conserved motifs that are essential for PglB function, these loops play a fundamental role in catalysis |
718913 |
